I-2-methyl-5-nitroimidazole
Ulwazi Oluyisisekelo:
Igama lamakhemikhali: 2-methyl-5-nitroimidazole;
Igama lesiNgisi: 2-Methyl-5-nitroimidazole;
Inombolo ye-CAS: 88054-22-2
Ifomula yemolekyuli: C4H5N3O2
Isisindo se-molecule: 127.1
Inombolo ye-EINECS: 618-108-7
Ifomula yesakhiwo:
Izigaba ezihlobene: izinto zokusetshenziswa; Abaphakathi kwezemithi; Izinto zokusetshenziswa kwemithi.
Ukuminyana :1.4± 0.1g/cm3
Iphoyinti lokubilisa :399.5±15.0 °C ku-760 mmHg
Iphoyinti lokuncibilika: 252-254ºC
Iphoyinti elikhanyayo :195.4±20.4 °C
Isisindo esinembile :127.038177
I-PSA:74.50000 LogP:-0.10
Ukubukeka: Ikristalu emhlophe
Umfutho womhwamuko:0.0±0.9 mmHg ku-25°C
Inkomba ye-refractive: 1.592
Izimo zokugcina: ivalwe endaweni epholile neyomile engu-0-6 ºC
Ukuzinza: ngeke kubole lapho isetshenziswa futhi igcinwe ngokwemithethonqubo.
| ukucaciswa | iyunithi | ejwayelekile |
| Ukubukeka | Njengempushana emhlophe noma ephuzi | |
| Okuqukethwe | % | ≥99% |
| Umswakama | % | ≤0.3 |
| I-Sulfate | % | ≤0.3 |
Ikakhulukazi esetshenziswa synthesis metronidazole, dimetazole kanye nezinye izidakamizwa intermediates.
Itholakala nge-nitrate ye-2-methylimidazole. Faka i-sulfuric acid, i-2-methylimidazole ne-sodium sulfate ebhodweni lokusabela, gudluza futhi ushise, engeza i-nitric acid ku-150-160 ℃, hlanganisa, landela ukusabela kwe-casket ihora elingu-1. Susa izinga lokushisa libe ngu-140℃ ngezansi, ngemva kokwengeza amanzi anamanzi ammonia ukuze ulungise i-pH ibe ngu-3.5-4, i-crystallization. Hlunga, geza ukuze ungathathi hlangothi, wome, 2-methyl-5-nitroimidazole.
Isikhwama sephepha esingu-25k se-kraft noma isikhwama esilukiwe (58×110) esifakwe isikhwama sepulasitiki, isikhwama sesitsha sokuthekelisa esingu-250kg (100×80); Ngokwezidingo zamakhasimende;
Isitoreji esivaliwe, esigcinwe endaweni epholile, emnyama, eyomile, isitoreji kanye nezinto zokuhamba kufanele kube lula, ukuvimbela umonakalo nomswakama, kuvinjelwe ngokuqinile nezidakamizwa ezixutshwe.
Indlela yokukhiqiza: Itholwe nge-nitrate ye-2-methylimidazole. Faka i-sulfuric acid, i-2-methylimidazole ne-sodium sulfate ebhodweni lokusabela, gudluza futhi ushise, engeza i-nitric acid ku-150-160 ℃, hlanganisa, landela ukusabela kwe-casket ihora elingu-1. Susa izinga lokushisa libe ngu-140℃ ngezansi, ngemva kokwengeza amanzi anamanzi ammonia ukuze ulungise i-pH ibe ngu-3.5-4, i-crystallization. Hlunga, geza ukuze ungathathi hlangothi, wome, 2-methyl-5-nitroimidazole.
