7-Amino-3-cephem-4-carboxylic acid
Ulwazi Oluyisisekelo:
Isibizo sesiNgisi:
7-ANCA;7-AMOCA;(6R,7R)-7-AMino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicAcid;7-NACA;7- I-NACA,7-ANCA;7-ANCAChemicalbookukungcola;CeftizoximeUkungcola9;CeftizoximeUkungcola16;Ceftizoximeintermediate(7-anca);7-amino-3-cephem-4-carboxylicacid
Inombolo ye-CAS: 36923-17-8
Ifomula yemolekyuli: C7H8N2O3S
Isisindo se-molecule: 200.21
Inombolo ye-EINECS: 609-312-7
Ifomula yesakhiwo:
Izigaba ezihlobene: Abaphakathi be-Organic; Abaphakathi kwezemithi; Izinto zokusetshenziswa kwemithi.
Indawo yokuncibilika: 215-218°C
Indawo yokubilisa: 536.9±50.0 °C(Kubikezelwe)
Ukuminyana: 1.69± 0.1g /cm3(Kubikezelwe)
Inkomba ye-refractive: 1.735 (isilinganiso)
Iphoyinti elikhanyayo: 278.508°C
I-Solubility: I-Soluble ku-acidic aqueous solution (kancane, ukushisisa), i-DMSO (kancane). Izakhiwo: I-crystalline powder emhlophe noma emhlophe.
Umfutho womhwamuko: 0mmHg ku-25°C
| ukucaciswa | iyunithi | ejwayelekile |
| Ukubukeka | I-crystalline powder emhlophe noma emhlophe | |
| Okuqukethwe okuyinhloko | % | ≥98.5% |
| Umswakama | % | ≤1 |
| I-Mono hybrid | % | ≤0.5 |
| Imfuhlumfuhlu ephelele | % | ≤1 |
I-Cephalosporin, esetshenziswa njengendawo ephakathi ye-cefbutan ne-cefazoxime.
I-sulfuric acid egxilile (104.3mL, 1.92mol) yengezwa emabhodleleni amathathu, kwase kwengezwa i-isophthalic acid (40g, 0.24mol), yanyakaziswa futhi yashiswa ibe ngu-60 ℃, ebanjelwe u-0.5h, kanye no-60% nitric acid (37.8g, 0.36) mol) yengezwe ukulawula idigri yokusheshisa amaconsi. Yengeze emahoreni angu-2. Ngemuva kwalokho, ukusabela kokugcina ukushisa ku-60 ℃ amahora ama-2. Phola ube ngaphansi kuka-50 ° C, bese ufaka u-100mL wamanzi. Impahla ipholile ekamelweni lokushisa, ithululelwe esihlungi, iphonswe ukuze isuse i-asidi yemfucuza, ikhekhe lokuhlunga lihlanjululwe ngamanzi, likhishwe ukuze liphinde likhanye, futhi umkhiqizo omhlophe wawungamagremu angu-34.6, isivuno sasingu-68.4%.
20Kg noma 25Kg/ ibhakede, ibhakede lekhadibhodi, elifakwe ungqimba olumhlophe kanye nesikhwama esimnyama se-polyethylene. 2℃-8℃ indawo eyomile, epholile, kude nendawo yokugcina ukukhanya, isebenza iminyaka emi-2.
