I-Sulfadiazine sodium iyimithi elwa namagciwane e-sulfonamide enemiphumela yokulwa namagciwane kuma-bacterium amaningi e-Gram-positive kanye ne-Gram-negative. Inemiphumela elwa namagciwane ku-Staphylococcus aureus engakhiqizi ama-enzyme, i-Streptococcus pyogenes, i-Streptococcus pneumoniae, i-Escherichia coli, i-Klebsiella, i-Salmonella, i-Shigella, i-Neisseria gonorrhoeae, i-Neisseria meningitidis, ne-Haemophilus influenzae. Ngaphezu kwalokho, iphinde isebenze ngokumelene ne-Chlamydia trachomatis, i-Nocardia asteroides, i-Plasmodium, ne-Toxoplasma in vitro. Umsebenzi we-antibacterial walo mkhiqizo uyafana nalowo we-sulfamethoxazole. Nokho, eminyakeni yamuva nje, ukumelana kwamagciwane kulo mkhiqizo kuye kwanda, ikakhulukazi iStreptococcus, Neisseria, ne-Enterobacteriaceae.