Izicelo ezibalulekile ze-nucleosides eguquliwe

Ukuqalisa

Ama-nucleosides, amabhlogo wokwakha ama-nucleic acid (DNA ne-RNA), adlala indima eyisisekelo kuzo zonke izinto eziphilayo. Ngokushintsha la ma-molekyuli, ososayensi bavule izicelo eziningi ezingaba khona ezicwaninganeni nomuthi. Kulesi sihloko, sizohlola ezinye zezicelo ezibalulekile zeI-nucleosides eguquliwe.

Indima ye-nucleosides eguquliwe

I-nucleosides eguquliwe yenziwa ngokuguqula ukwakheka kwe-nucleosides yemvelo, efana ne-adenosine, i-guanosine, i-cytidine, ne-uridine. Lokhu kuguqulwa kungafaka izinguquko ezisekelweni, ushukela, noma zombili. Isakhiwo esishintshiwe singadlulisela izakhiwo ezintsha kwi-nucleoside eguquliwe, okwenza kufanelekile ukuthola izinhlelo ezahlukahlukene.

Izicelo ezibalulekile

Ukutholwa Kwezidakamizwa:

Ama-Anticancer Agents: Kusetshenziswe i-nucleosides eguquliwe ukuthuthukisa uhla lwezidakamizwa zezi-anticancer. Isibonelo, zingenzelwe ukuvimbela ukuhlanganiswa kwe-DNA noma ukuqondisa amaseli athile umdlavuza.

Ajenti Antiviral: I-Nucleosides eguquliwe isetshenziselwa ukudala izidakamizwa ezilwa namagciwane ezingavimba ukuphindaphindwa kwegciwane. Isibonelo esidume kakhulu ukusetshenziswa kwe-nucleosides eguquliwe emithethweni yokugoma ye-MRNA eyi-19.

Ama-antibacterial abethe: ama-nucleosides aguquliwe nawo abonise isithembiso ekwakhiweni kwama-antibiotiotic amasha.

Ubunjiniyela bezakhi zofuzo:

Imithi yokugoma i-MRNA: I-Nucleosides eguquliwe iyizakhi ezibalulekile zemithi yokugoma i-MRNA, ngoba ingathuthukisa ukuqina kanye nokumenyezelwa kwe-MRNA.

I-Antisense Oligonucleotides: Lawa ma-molecule, aklanyelwe ukubopha ukulandelana okuthile kwe-MRNA, angashintshwa ukuze athuthukise ukuqina kwawo kanye nokucaciswa kwawo.

UTene Therapy: I-nucleosides eguquliwe ingasetjenziselwa ukudala ama-oligonucleotides aguquliwe wezinhlelo zokwelashwa zeGene Therapy, njengokulungisa iziphambeko zofuzo.

Amathuluzi okucwaninga:

I-nucleic acid iphenya: ama-nucleosides aguquliwe angafakwa kuma-proup asetshenziswe kumasu anjenge-fluorescence ku-situ hybridization (inhlanzi) kanye nokuhlaziywa kwe-microarray.

Ama-Aptamers: Lezi zinto ezihlangene ne-nucleic acidi eyodwa zingashintshwa ukuze zibophezele kumigomo ethile, njengamaprotheni noma ama-molecule amancane, futhi anezicelo zokuxilongwa kanye nokwelapha.

Izinzuzo ze-nucleosides eguquliwe

Ukuqina okuthuthukisiwe: ama-nucleosides aguquliwe angathuthukisa ukuqina kwama-acid ama-nucleic, abenze bazwele ngokwengeziwe ukucekelwa phansi ngama-enzyme.

Ukucaciswa Okucacisiwe

Ukuthuthukiswa kwamaselula okuthuthukisiwe: I-nucleosides eguquliwe ingenziwa ukuthuthukisa ukuthuthuka kwazo kwamaselula, yandisa ukusebenza kwayo ezinhlelweni zokwelapha.

Ukugcina

Ama-nucleosides aguquliwe aguqule izinkambu ezahlukahlukene, ekutholweni kwezidakamizwa ezenjiniyela zofuzo. Ukuguquguquka okuhlukahlukene kanye nekhono lokuhambisana nezinhlelo ezithile kuzanzele amathuluzi agxile kubacwaningi nodokotela. Njengoba ukuqonda kwethu amakhemikhali e-nucleic acid kuyaqhubeka ukukhula, singalindela ukubona izinhlelo ezintsha kakhulu ze-nucleososososososososo esiguquliwe ngokuzayo.