I-sulfamethazine
Ulwazi Oluyisisekelo:
Igama lomkhiqizo: Sulfamethazine
Isibizo: sulfadimethylpyrimidine
Ifomula yamakhemikhali: C12H14N4O2S
Ifomula yesakhiwo:
Isisindo se-molecule: 278.33
Inombolo yokungena ye-CAS: 57-68-1
Inombolo yokungenela ye-EINECS: 200-346-4
Izakhiwo zomzimba namakhemikhali
Ukuminyana: 1.392g/cm3
Indawo yokuncibilika: 197°C
Indawo yokubilisa: 526.2ºC
Iphoyinti elikhanyayo: 272.1ºC
Ukubukeka: i-crystalline powder emhlophe
Ukuncibilika: cishe akuncibiliki emanzini, akuncibiliki ku-ether, kuncibilika kalula ku-asidi exubileyo noma isixazululo se-alkali
I-Sulfadiazine iyi-antibiotic ye-sulfanilamide ene-spectrum ye-antibacterial efanayo ne-sulfadiazine. Inemiphumela elwa namagciwane kumagciwane e-enterobacteriaceae afana ne-non-zymogenic Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, njll. Neisseria gonorrhoea, Neisseria meningitidis kanye neHaemoenza. Kodwa-ke, ukumelana kwamagciwane kumkhiqizo kwanda, ikakhulukazi i-streptococcus, i-Neisseria ne-Enterobacteriaceae bacteria. Ama-sulfonamides ama-bacteriostatic agents ane-spectrum ebanzi, afana ngesakhiwo ne-p-aminobenzoic acid (PABA), angakwazi ukusebenza ngokuncintisana ku-dihydrofolate synthetase kuma-bacterium, ngaleyo ndlela avimbele i-PABA ukuthi isetshenziswe njengempahla eluhlaza ukuze kuhlanganiswe i-folate edingwa amagciwane kanye nokunciphisa inani I-tetrahydrofolate esebenzayo ye-metabolic. Lesi sakamuva siyisithako esibalulekile sokwenziwa kwe-purines, i-thymidine nucleosides ne-deoxyribonucleic acid (DNA), ngakho-ke kuvimbela ukukhula nokukhiqizwa kwamagciwane.
Isetshenziselwa ikakhulukazi izifo ezithambile ezibangelwa amagciwane azwelayo, njenge-acute elula ephansi ye-urinary tract infection, i-acute otitis media kanye nokutheleleka kwezicubu ezithambile zesikhumba.
